Bill Spencer moved from Arkansas to Saint Louis during the Depression. He was looking for work. He met his wife Irene Harlow when they were bith working atthe same restaurant. They married in 1941. They purchased an.existing restaurant. Lee Grill at 303 South Kirkwood Road. They renamed it Spencer’s. The restaurant at this location operated only 2 years.

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In 1947, they reopened Spencer’s at a new location–223 Kirkwood Road. Their aim was to capture business from Route 66. Initially, they were opened 24 hours. Bill maintained ownership of the building until 1980. This was the time of his retirement.
Subsequently, the restaurant had six owners. Currently, the owners are Mike and Meredith Chadwick.
